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IMOVANE (ZOPICLONE): DRUG INTERACTIONS

Alcohol

Concomitant intake of Imovane (Zopiclone) tablets with alcohol is not recommended. The sedative effect of zopiclone may be enhanced when the product is used in combination with alcohol.

CNS Depressants

Additive CNS depressant effects should be expected if zopiclone is administered concomitantly with other medications which themselves produce CNS depression, for example, benzodiazepines, barbiturates, alcohol, tricyclic antidepressants, sedatives, non-selective MAO inhibitors, skeletal muscle relaxants, phenothiazines and other antipsychotics, antihistamines, anaesthetics, narcotic analgesics, neuroleptics, antiepileptics, anxiolytics. In the case of narcotic analgesics, enhancement of euphoria may also occur leading to an increase in psychic dependence.

Other

Erythromycin has been reported to increase significantly zopiclone concentrations at 0.5 and 1 hour after ingestion of Zopiclone (Imovane). The total AUC of zopiclone increased by 80% in 10 healthy volunteers. Accelerated absorption of zopiclone in the presence of erythromycin may lead to faster hypnotic effects.

Plasma levels of zopiclone may be increased when co-administered with CYP3A4 inhibitors such as clarithromycin, erythromycin, ketoconazole, itraconazole, and ritonavir.

Plasma levels of Imovane (Zopiclone) may be decreased when co-administered with CYP3A4 inducers, such as carbamazepine, rifampicin, phenobarbital, phenytoin, and St. John's wort.

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