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IMOVANE (ZOPICLONE): OVERDOSAGE
Overdose of Zopiclone (Imovane) can be manifested by varying degrees of CNS depression ranging from drowsiness to coma according to the quantity ingested. In mild cases, symptoms include confusion, drowsiness and lethargy. In more severe cases, symptoms may include hypotonia, ataxia, hypotension, respiratory depression, methaemoglobinaemia, and coma. Overdosage could be life threatening when combined with other CNS depressants, including alcohol. Other risk factors, such as the presence of concomitant illness and the debilitated state of the patient, may contribute to the severity of symptoms and very rarely can result in fatal outcome.
Symptomatic and supportive treatment of overdosage by Imovane (Zopiclone) tablets in an adequate clinical environment is recommended, attention should be paid to respiratory and cardiovascular functions. Activated charcoal is only useful when performed soon after ingestion. Haemodialysis is of no value due to the large volume of distribution of zopiclone. Flumazenil may be useful as an antidote. As in the management of overdosage with any medication, it should be borne in mind that multiple agents may have been taken.
Also your should contact a local poisons information centre for advice on management of overdosage.
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